Four people are dead and two others are hurt, one of them seriously, after a multi-vehicle collision on Long Island's Southern State Parkway early Tuesday that apparently was caused by a wrong-way driver, New York State Police said.

State Police said they received a call about an eastbound crash involving three vehicles and a motorcycle around 5:10 a.m. near exit 29 in Nassau County's Town of Oyster Bay. Moments earlier, the 911 call about the wrong-way driver came in.

According to State Police, a Toyota sedan, with the driver as the only occupant, was traveling westbound in the eastbound lanes when it struck an SUV carrying four people head on. A third vehicle, also an SUV, with its driver as the only occupant, tried to avoid the collision, but struck the Toyota. A motorcyclist also tried to avoid the crash, but lost control and hit debris from the crash.

The driver of the sedan and three occupants of the first SUV all died at the scene; the fourth occupant is in serious condition. 

The driver of the third vehicle wasn't hurt; the motorcyclist suffered non life-threatening injuries. Authorities are expected to release additional information later Tuesday.

The Southern State Parkway was closed in the area as authorities investigated, but has since reopened.

State Police ask anyone with information on the collision to call (631) 756-3300.